89-7763-71 ［取扱停止］Recombinant Human PDK/PDZ binding kinase/TOPK Protein (His Tag) 20ug PKSH031457
[Elabscience]
特徴
- 背景：PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.This mitotic kinase phosphorylates MAP kinase p38 and seems to be active in mitosis. When phosphorylated, PBK forms a protein-protein interaction with tumor suppressor p53 (TP53), leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. The expression level of PBK is thus upregulated in a variety of neoplasms including hematological malignancies.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 80 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_060962.2
- タグ種類：C-His
- アミノ酸配列：Met 1-Val 322
- 遺伝子構造：A DNA sequence encoding the full length of human PBK (NP_060962.2) (Met 1-Val 322) was fused with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：CT84;HEL164;Nori-3;SPK;TOPK
- 分子量：37 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105633-Elabscience-PKSH031457.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7763-72
Recombinant Human PDK/PDZ binding kinase/TOPK Protein (His Tag) 50ug
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89-7763-71
Recombinant Human PDK/PDZ binding kinase/TOPK Protein (His Tag) 20ug
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