89-7763-70 Recombinant Human DDR1 Kinase/MCK10 Protein (His Tag) 100ug PKSH031456
[Elabscience]
特徴
- 背景：Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_001945.3
- タグ種類：C-His
- アミノ酸配列：Met 1-Thr 416
- 遺伝子構造：A DNA sequence encoding the extracellular domain of human DDR1 isoform b (NP_001945.3) (Met 1-Thr 416) was expressed, with a C-terminal polyhistidine tag.
- 別名（遺伝子名）：CAK;CD167;DDR;EDDR1;HGK2;MCK10;NEP;NTRK4;PTK3;PTK3A;RTK6;TRKE
- 分子量：45.7 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37944-Elabscience-PKSH031456.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7763-70
Recombinant Human DDR1 Kinase/MCK10 Protein (His Tag) 100ug
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89-7763-69
Recombinant Human DDR1 Kinase/MCK10 Protein (His Tag) 50ug
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