89-7763-67 ［取扱停止］Recombinant Human LRAP/ERAP2 Protein (His Tag)(Active) 20ug PKSH031454
[Elabscience]
特徴
- 背景：Leukocyte-derived arginine aminopeptidase (LRAP), also known as endoplasmic reticulum-aminopeptidase 2 (ERAP2), is the second identified aminopeptidase localized in the in the lumenal side of endoplasmic reticulum (ER) processing antigenic peptides presented to major histocompatibility complex (MHC) class I molecules. It is a 960-amino acid protein with significant homology to placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase. LRAP preferentially hydrolyzes the basic residues Arg and Lys, and contains the HEXXH(X)18E zinc-binding motif, which is the characteristic of the M1 family of zinc metallopeptidases which also includes PILS/ARTS1/ERAP1 and LNPEP/PLAP. Induced by interferon-gamma, LRAP is able to trim various MHC class I antigenic peptide precursors.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 98 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_071745.1
- タグ種類：N-His
- アミノ酸配列：Ala 56-Thr 960
- 遺伝子構造：A DNA sequence encoding the lumenal domain of human ERAP2 (NP_071745.1) (Ala 56-Thr 960) was expressed with a polyhistidine tag at the N-terminus.
- 活性：Measured by its ability to cleave the fluorogenic peptide substrate, Arg-7-amido-4-methylcoumarin (Arg-AMC). The specific activity is >50 pmoles/min/μg.
- 別名（遺伝子名）：FLJ23633;FLJ23701;FLJ23807;L-RAP;LRAP;LRAP.ERAP2
- 分子量：106 kDa
- 組成：Lyophilized from sterile 12.5mM Tris, 75mM NaCl, pH 7.5, 50% glycercol
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105632-Elabscience-PKSH031454.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7763-66
Recombinant Human LRAP/ERAP2 Protein (His Tag)(Active) 10ug
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89-7763-67
Recombinant Human LRAP/ERAP2 Protein (His Tag)(Active) 20ug
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