89-7763-48 ［取扱停止］Recombinant Human MICB Protein (His Tag)(Active) 100ug PKSH031443
[Elabscience]
特徴
- 背景：MHC class I polypeptide-related sequence B; also known as MICB; is a heavily glycosylated protein serving as a ligand for the type I I receptor NKG2D. MICB shares 85% amino acid identity with MICA; a closely related protein; both of which contain three extracellular immunoglobulin-like domains; but without capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen; binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells; CD8+αβ T cells; and γδ T cells on which the receptor is expressed. MICA/B are minimally expressed on normal cells; but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B recognition thus is involved in tumor surveillance; viral infections; and autoimmune diseases.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 98 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_005922.2
- タグ種類：C-His
- アミノ酸配列：Met 1-Gly 298
- 遺伝子構造：A DNA sequence encoding the extracellular domain of human MICB (NP_005922.2) (Met 1-Gly 298) was expressed with a C-terminal polyhistidine tag.
- 活性：Immobilized human MICB-His at 10 μg/ml (100 μl/well) can bind human NKG2D; The EC50 of human NKG2D is 0.52-1.2 μg/ml.
- 別名（遺伝子名）：PERB11.2
- 分子量：33 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105625-Elabscience-PKSH031443.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7763-47
Recombinant Human MICB Protein (His Tag)(Active) 50ug
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89-7763-48
Recombinant Human MICB Protein (His Tag)(Active) 100ug
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