89-7763-32 ［取扱停止］Recombinant Human CD40/TNFRSF5 Protein (His & Fc Tag)(Active) 100ug PKSH031434
[Elabscience]
特徴
- 背景：CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.Immune CheckpointImmune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: ICC Antibodies Immune Checkpoint Detection: IP Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_001241.1
- タグ種類：C-His & Fc
- アミノ酸配列：Met 1-Arg193
- 遺伝子構造：A DNA sequence encoding the human CD40 (NP_001241.1) extracellular domain (Met 1-Arg193) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- 活性：Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD40 at 2 μg/ml (100 μl/well) can bind biotinylated human CD40L with a linear range of 7.8-125 ng/ml.
- 別名（遺伝子名）：Tumor Necrosis Factor Receptor Superfamily member 5; B-Cell Surface Antigen CD40; Bp50; CD40L Receptor; CDw40; CD40; TNFRSF5
- 分子量：47.3 kDa
- 組成：Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37934-Elabscience-PKSH031434.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7763-32
Recombinant Human CD40/TNFRSF5 Protein (His & Fc Tag)(Active) 100ug
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89-7763-31
Recombinant Human CD40/TNFRSF5 Protein (His & Fc Tag)(Active) 50ug
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