89-7763-06 Recombinant Human VEGFR3/FLT4 Protein (His Tag)(Active) 100ug PKSH031419
[Elabscience]
特徴
- 背景：Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_002011.2
- タグ種類：C-His
- アミノ酸配列：Met 1-Ile 776
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met 1-Ile 776) of human VEGFR3 (NP_002011.2) was expressed with a C-terminal polyhistidine tag.
- 活性：Measured by its binding ability in a functional ELISA.Immobilized human VEGF-C at 10 μg/mL (100 μl/well) can bind human VEGFR3-his. The EC50 of human VEGFR3-his is 0.011 μg/mL. Measured by its ability to bind human VEGF-D in a functional ELISA.
- 別名（遺伝子名）：FLT-4;FLT-41;FLT41;LMPH1A;PCL;VEGF Receptor 3;VEGFR-3;VEGFR3
- 分子量：86 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37926-Elabscience-PKSH031419.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7763-05
Recombinant Human VEGFR3/FLT4 Protein (His Tag)(Active) 50ug
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89-7763-06
Recombinant Human VEGFR3/FLT4 Protein (His Tag)(Active) 100ug
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