89-7762-85 Recombinant Human CEACAM6/CD66c Protein (His Tag)(Active) 100ug PKSH031409
[Elabscience]
特徴
- 背景：Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It s a glycosylphosphatidylinositol-linked immunoglobulin superfamily member that is overexpressed in a variety of human cancers, including colon, breast and lung and is associated with tumourigenesis, tumour cell adhesion, invasion and metastasis. CEACAM6 is a unique mediator of migration and invasion of drug resistant oestrogen-deprived breast cancer cells, and this protein could be an important biomarker of metastasis. CEACAM6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_002474.3
- タグ種類：C-His
- アミノ酸配列：Met 1-Gly 320
- 遺伝子構造：A DNA sequence encoding the human CEACAM6 (NP_002474.3) (Met 1-Gly 320) with a C-terminal polyhistidine tag was expressed.
- 活性：Measured by its binding ability in a functional ELISA. Immobilized human CEACAM6-his at 10 μg/mL (100 μl/well) can bind biotinylated human CEACAM8-his, The EC50 of biotinylated human CEACAM8-his is 0.17 μg/mL.
- 別名（遺伝子名）：CD66c;CEA;CEAL;NCA
- 分子量：32.6 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37917-Elabscience-PKSH031409.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
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89-7762-84
Recombinant Human CEACAM6/CD66c Protein (His Tag)(Active) 50ug
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89-7762-85
Recombinant Human CEACAM6/CD66c Protein (His Tag)(Active) 100ug
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