89-7762-69 Recombinant Human 14-3-3 sigma/YWHAS Protein (GST Tag) 100ug PKSH031401
[Elabscience]
特徴
- 背景：14-3-3 protein sigma (YWHAS); also known as stratifin (SFN) and epithelial cell marker protein 1; is a member of the14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases; phosphatases; and transmembrane receptors; and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2; and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally; YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 94 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：NP_006133.1
- タグ種類：N-GST
- アミノ酸配列：Met 1-Ser 248
- 遺伝子構造：A DNA sequence encoding the human SFN (NP_006133.1) (Met 1-Ser 248) was fused with the GST tag at the N-terminus.
- 別名（遺伝子名）：14-3-3 Protein Sigma; Epithelial Cell Marker Protein 1; Stratifin; SFN; HME1
- 分子量：50.1 kDa
- 組成：Lyophilized from sterile 20mM Tris; 150mM NaCl; 10mM GSH; 25% glycerol; pH 8.0
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105611-Elabscience-PKSH031401.pdf
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89-7762-69
Recombinant Human 14-3-3 sigma/YWHAS Protein (GST Tag) 100ug
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89-7762-68
Recombinant Human 14-3-3 sigma/YWHAS Protein (GST Tag) 20ug
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