89-7762-50 ［取扱停止］Recombinant Human PLA2G7/Lp-PLA2 Protein (His Tag)(Active) 10ug PKSH031390
[Elabscience]
特徴
- 背景：Platelet-activating factor acetylhydrolase; also known as 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycero-phosphocholine esterase; Group-VIIA phospholipase A2; LDL-associated phospholipase A2; PAF 2-acylhydrolase; PLA2G7 and PAFAH; is secreted protein which belongs to the AB hydrolase superfamily and Lipase family. PLA2G7 / PAFAH modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. It has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids. PLA2G7 / PAFAH is a potent pro- and anti-inflammatory molecule that has been implicated in multiple inflammatory disease processes; including cardiovascular disease. PLA2G7 also represents an important; potentially functional candidate in the pathophysiology of coronary artery disease (CAD). Defects in PLA2G7 are the cause of platelet-activating factor acetylhydrolase deficiency (PLA2G7 deficiency). It is a trait which is present in 27% of Japanese. It could have a significant physiologic effect in the presence of inflammatory bodily responses.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 88 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q13093-1
- タグ種類：C-His
- アミノ酸配列：Met 1-Asn 441
- 遺伝子構造：A DNA sequence encoding the human PLA2G7 (Q13093-1) precursor (Met 1-Asn 441) was expressed; with a C-terminal polyhistidine tag.
- 活性：Measured by its ability to cleave a colorimetric peptide substrate; 1O-hexadecyl-2-deoxy-2-thio Sacetylsnglyceryl-3-phosphoryl choline (2-Thio-PAF); in the presence of 5; 5’Dithiobis(2-nitrobenzoic acid) (DTNB).The specific activity is >5000 pmoles/min/μg.
- 別名（遺伝子名）：2-acetyl-1-alkylglycerophosphocholine esterase; EC 3.1.1; EC 3.1.1.47;1-alkyl-2-acetylglycerophosphocholine esterase; Group-VIIA phospholipase A2; gVIIA-PLA2; LDL-associated phospholipase A2; LDL-PLA(2); LDL-PLA2; lipoprotein-associated phospholipase A2; LpPLA2; Lp-PLA2; PAF acetylhydrolase; PAF-AH; PAFAHPAF 2-acylhydrolase; phospholipase A2; group VII (platelet-activating factor acetylhydrolase; PLA2G7; plasma); platelet-activating factor acetylhydrolase
- 分子量：49.2 kDa
- 組成：Lyophilized from sterile 50mM NaAc; 150mM NaCl; 10% glycerol; pH 5.0
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37905-Elabscience-PKSH031390.pdf
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89-7762-50
Recombinant Human PLA2G7/Lp-PLA2 Protein (His Tag)(Active) 10ug
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89-7762-51
Recombinant Human PLA2G7/Lp-PLA2 Protein (His Tag)(Active) 20ug
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