89-7762-13 ［取扱停止］Recombinant Human IL17RA Protein (His & Fc Tag)(Active) 200ug PKSH031369
[Elabscience]
特徴
- 背景：Interleukin-17 receptor (IL-17R); also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217); is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors; this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections; selective against Candida. It is characterized by persistent and/or recurrent infections of the skin; nails and mucous membranes caused by organisms of the genus Candida; mainly Candida albicans.
仕様
- サイズ：200ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_055154.3
- タグ種類：C-His & Fc
- アミノ酸配列：Met 1-Trp 320
- 遺伝子構造：A DNA sequence encoding the extracellular domain of human IL17RA (NP_055154.3) (Met 1-Trp 320) was was fused with the C-terminal polyhistidine-taggged Fc region of human IgG1 at the C-terminus.
- 活性：1. Measured by its ability to bind human IL17F in a functional ELISA.2. Measured by its binding ability in a functional ELISA.3. Immobilized recombinant human IL17A at 20 μg/ml (100 μl/well) can bind human IL17RA with a linear range of 32-160 ng/ml.
- 別名（遺伝子名）：CANDF5;CD217;CDw217;hIL-17R;IL-17RA;IL17R
- 分子量：61.5 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37891-Elabscience-PKSH031369.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7762-12
Recombinant Human IL17RA Protein (His & Fc Tag)(Active) 100ug
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89-7762-13
Recombinant Human IL17RA Protein (His & Fc Tag)(Active) 200ug
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