89-7761-87 ［取扱停止］Recombinant Human uPAR Protein (His Tag)(Active) 200ug PKSH031353
[Elabscience]
特徴
- 背景：Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. uPAR and uPA levels in both resected tumor tissue and plasma are of independent prognostic significance for patient survival in several types of human cancer. This system has classically been thought to drive tumor progression by mediating directed extracellular proteolysis on the surface of migrating or invading cells, and intervening with this proteolysis by targeting uPAR has been proposed to represent a novel approach for inhibiting tumor progression. uPAR, also known as PLAUR or CD87, has been implicated in the growth, metastasis, and angiogenesis of several solid and hemotologic malignancies. uPAR is a highly glycosylated, 55-60kDa integral membrane protein linked to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. It is part of a cell surface system that also consists of the serine protease uPA and several specific inhibitors (plasminogen activator inhibitors 1 and 2). Additionally, the analysis of CD87 (urokinase-type plasminogen activator receptor - uPAR) expression has a potential role in the diagnostic or prognostic work-up of several hematological malignancies, particularly acute leukemia and multiple myeloma.
仕様
- サイズ：200ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 98 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q03405-1
- タグ種類：C-His
- アミノ酸配列：Met 1-Arg 303
- 遺伝子構造：A DNA sequence encoding the human UPAR isoform 1 (Q03405-1) (Met 1-Arg 303) without the pro peptide was expressed, with a carboxy-terminal polyhistidine tag.
- 活性：Measured by its binding ability in a functional ELISA . Immobilized human uPAR at 5 μg/ml (100 μl/well) can bind biotinylated human UPA with a linear ranger of 40-1000 ng/ml.
- 別名（遺伝子名）：Urokinase Plasminogen Activator Surface Receptor; U-PAR; uPAR; Monocyte activation antigen;Mo3; CD87; PLAUR; MO3; UPAR
- 分子量：32.8 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37881-Elabscience-PKSH031353.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7761-87
Recombinant Human uPAR Protein (His Tag)(Active) 200ug
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89-7761-86
Recombinant Human uPAR Protein (His Tag)(Active) 100ug
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