89-7761-50 ［取扱停止］Recombinant Human Renin Protein (His Tag)(Active) 20ug PKSH031332
[Elabscience]
特徴
- 背景：Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mRNA available for translation. Renin-1 is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. It is expressed at relatively low levels in mouse SMG and kidney. Ren-2 is expressed at high levels in the mouse SMG and at very low levels, if at all, in the kidney. Ren-1 and Ren-2 are closely linked on mouse chromosome 1, show extensive homology in coding and noncoding regions and provide a model for studying the regulation of gene expression.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_000528.1
- タグ種類：C-His
- アミノ酸配列：Met 1-Arg 406
- 遺伝子構造：A DNA sequence encoding the human Renin (NP_000528.1) precursor (Met 1-Arg 406) was expressed with a polyhistidine tag at the C-terminus.
- 活性：Measured by its binding ability in a functional ELISA.Immobilized human RENIN-His at 10 μg/ml (100 μl/well) can bind biotinylated human AGT-His with a linear range of 0.156-5.0 μg/ml.
- 別名（遺伝子名）：Renin; Angiotensinogenase; REN; Angiotensin-forming enzyme
- 分子量：43.7 kDa
- 組成：Lyophilized from sterile 25mM MES, 150mM NaCl, pH6.5
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37864-Elabscience-PKSH031332.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7761-51
Recombinant Human Renin Protein (His Tag)(Active) 50ug
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89-7761-50
Recombinant Human Renin Protein (His Tag)(Active) 20ug
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