89-7759-73 ［取扱停止］Recombinant Human CTLA4/CD152 Protein (His Tag)(Active) 200ug PKSH031232
[Elabscience]
特徴
- 背景：Cytotoxic T-lymphocyte protein 4; also known as CTLA4 and CD152; is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members; CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells; whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role; CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular; recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells; termed regulatory T cells (Treg).Immune CheckpointImmune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IP Antibodies Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint Proteins CTLA4 / CD152 Immune Checkpoint ProteinsImmune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：200ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_005205.2
- タグ種類：C-His
- アミノ酸配列：Met 1-Phe 162
- 遺伝子構造：A DNA sequence encoding the human CTLA4 (NP_005205.2) extracellular domain (Met 1-Phe 162) was fused with the a polyhistidine tag at the C-terminus.
- 活性：Measured by its binding ability in a functional ELISA. Immobilized human CTLA4 at 10 μg/mL (100 μl/well) can bind human B7-1/Fc; The EC50 of human B7-1/Fc is 14 ng/mL.3. Immobilized human CTLA4 at 10 μg/mL (100 μl/well) can bind human B7-2/Fch; The EC50 of human B7-2/Fch is 53 ng/mL.
- 別名（遺伝子名）：ALPS5;CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;IDDM12
- 分子量：15 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37791-Elabscience-PKSH031232.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7759-73
Recombinant Human CTLA4/CD152 Protein (His Tag)(Active) 200ug
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89-7759-72
Recombinant Human CTLA4/CD152 Protein (His Tag)(Active) 100ug
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