89-7759-41 Recombinant Human CD68/Macrosialin Protein (aa 1-319, His Tag) 100ug PKSH031214
[Elabscience]
特徴
- 背景：Macrosialin, also known as CD68 and Gp110, is a single-pass type I membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 98 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P34810-1
- タグ種類：C-His
- アミノ酸配列：Met 1-Ser 319
- 遺伝子構造：A DNA sequence encoding the human CD68 (Met 1-Ser 319) was expressed, with a C-terminal polyhistidine tag.
- 別名（遺伝子名）：GP110;LAMP4;SCARD1
- 分子量：32.9 kDa
- 組成：Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37781-Elabscience-PKSH031214.pdf
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89-7759-40
Recombinant Human CD68/Macrosialin Protein (aa 1-319, His Tag) 50ug
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89-7759-41
Recombinant Human CD68/Macrosialin Protein (aa 1-319, His Tag) 100ug
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