特徴
- 背景：Cysteine and glycine-rich protein 1, also known as Cysteine-rich protein 1, CSRP1 and CSRP, is a member of the CSRP family which may be involved in regulatory processes important for development and cellular differentiation. CSRP1 contains two LIM zinc-binding domains. The LIM / double zinc-finger motif found in CSRP1 is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Zebrafish CSRP1 is expressed in the mesendoderm and its derivatives. CSRP1 interacts with Dishevelled 2 (Dvl2) and Diversin (Div), which control cell morphology and other dynamic cell behaviors via the noncanonical Wnt and JNK pathways. When CSRP1 message is knocked down, abnormal convergent extension cell movement is induced, resulting in severe deformities in midline structures. In addition, cardiac bifida is induced as a consequence of defects in cardiac mesoderm cell migration. CSRP1 acts as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：NP_004069.1
- タグ種類：C-His
- アミノ酸配列：Met 1-Glu 193
- 遺伝子構造：A DNA sequence encoding the human CSRP1 (NP_004069.1) (Met 1-Glu 193) was expressed, with a polyhistide tag at the C-terminus.
- 別名（遺伝子名）：CRP;CRP1;CSRP;CYRP;D1S181E;HEL-141
- 分子量：21.4 kDa
- 組成：Lyophilized from sterile 10mM Na2HPO4, 2mM KH2PO4, 2.7mM KCl, 500mM NaCl, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37779-Elabscience-PKSH031212.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7759-39
Recombinant Human CSRP1 Protein (His Tag) 50ug
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89-7759-38
Recombinant Human CSRP1 Protein (His Tag) 20ug
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