89-7758-95 ［取扱停止］Recombinant Human SMYD3/ZMYND1 Protein (His&FLAG Tag) 20ug PKSH031188
[Elabscience]
特徴
- 背景：SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger and one SET domain. SMYD3 is a histone H3 lysine-4-specific methyltransferase. It is expressed in skeletal muscles and testis. It is overexpressed in a majority of colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC). SMYD3 plays an important role in transcriptional regulation in human carcinogenesis. It activates the transcription of a set of downstream genes. Of these downstream genes, there are several oncogenes and genes associated with cell adhesion (including those of N-Myc, CrkL, Wnt10b, L-selectin, CD31 and galectin-4), which have been shown to have effects on cell viability, adhesion, migration and metastasis. Increased SMYD3 expression is essential for the proliferation of breast cancer cells. SMYD3 may be a promising new target of therapeutic intervention for the treatment of cancers or other pathological processes associated with cell adhesion and migration.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 70 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_001161212.1
- タグ種類：C-His & N-FLAG
- アミノ酸配列：Met 1-Ser 428
- 遺伝子構造：A DNA sequence encoding the human SMYD3 isoform 1 (NP_001161212.1) (Met 1-Ser 428) was fused with the flag tag at the N-terminus. and the Histidine tag at the C-terminus.
- 別名（遺伝子名）：bA74P14.1;KMT3E;ZMYND1;ZNFN3A1
- 分子量：51.5 kDa
- 組成：Lyophilized from sterile 25mM Tris-HCl, 100mM NaCl, 20% glycerol, 3mM DTT, pH 8.0
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37758-Elabscience-PKSH031188.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7758-95
Recombinant Human SMYD3/ZMYND1 Protein (His&FLAG Tag) 20ug
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89-7758-96
Recombinant Human SMYD3/ZMYND1 Protein (His&FLAG Tag) 50ug
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