89-7758-45 ［取扱停止］Recombinant Human GPNMB Protein (aa 1-474, His Tag) 50ug PKSH031159
[Elabscience]
特徴
- 背景：GPNMB belongs to the PMEL / NMB family; also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ); is a transmembrane glycoprotein that is expressed in numerous cells; including osteoclasts; macrophages; dendritic cells; and tumor cells. It is suggested to influence osteoblast maturation; cell adhesion and migration. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization; and functions as a negative regulator of inflammation in macrophages. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. The early-phase upregulation of Osteoactivin expression in the tubular epithelium in response to renal injury might play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats. Osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 98 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q14956-2
- タグ種類：C-His
- アミノ酸配列：Met 1-Pro 474
- 遺伝子構造：A DNA sequence encoding the human GPNMB isoform 2 (Q14956-2) extracellular domain (Met 1-Pro 474) was fused with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：Transmembrane Glycoprotein NMB; Transmembrane Glycoprotein HGFIN; GPNMB; HGFIN;NMB;Osteoactivin
- 分子量：52.1 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37737-Elabscience-PKSH031159.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7758-46
Recombinant Human GPNMB Protein (aa 1-474, His Tag) 100ug
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89-7758-45
Recombinant Human GPNMB Protein (aa 1-474, His Tag) 50ug
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