89-7757-13 ［取扱停止］Recombinant Human EDAR/DL Protein (Fc Tag) 200ug PKSH031081
[Elabscience]
特徴
- 背景：Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in signaling centers regulating key steps in morphogenesis. activin signaling from mesenchyme induces the expression of the TNF receptor edar in the epithelial signaling centers; thus making them responsive to Wnt-induced ectodysplasin from the nearby ectoderm. This is the first demonstration of integration of the Wnt; activin; and TNF signaling pathways. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA); also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis); abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
仕様
- サイズ：200ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 96 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_071731.1
- タグ種類：C-Fc
- アミノ酸配列：Met 1-Ile 189
- 遺伝子構造：A DNA sequence encoding the human EDAR (NP_071731.1) extracellular domain (Met 1-Ile 189) was fused with the Fc region of human IgG1 at the C-terminus.
- 別名（遺伝子名）：DL;ECTD10A;ECTD10B;ED1R;ED3;ED5;EDA-A1R;EDA1R;EDA3;HRM1
- 分子量：44.6 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37679-Elabscience-PKSH031081.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7757-12
Recombinant Human EDAR/DL Protein (Fc Tag) 100ug
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89-7757-13
Recombinant Human EDAR/DL Protein (Fc Tag) 200ug
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