89-7756-89 ［取扱停止］Recombinant Human Neuregulin-1/NRG1-‑b1 Protein (EGF Domain, Fc Tag)(Active) 5ug PKSH031068
[Elabscience]
特徴
- 背景：Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development; neurotransmission; and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems; and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder; with etiology likely due to epistasis.
仕様
- サイズ：5ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 86 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：Q02297-6
- タグ種類：N-Fc
- アミノ酸配列：Thr 176-Lys 246
- 遺伝子構造：A DNA sequence encoding the EGF-like domain (Thr 176-Lys 246) of human NRG1 isoform beta1 (Q02297-6) was fused with the Fc region of human IgG1 at the N-terminus.
- 活性：1. Measured by its binding ability in a functional ELISA.2. Immobilized Rhesus ErbB3 at 2 μg/mL (100 μl/well) can bind human NRG1 (isoform Beta1); The EC50 of human NRG1 (isoform Beta1) is 0.58 μg/mL.3. Immobilized human ErbB3 at 2 μg/mL (100 μl/well) can bind human NRG1 (isoform Beta1); The EC50 of human NRG1 (isoform Beta1) is 0.43 μg/mL.
- 別名（遺伝子名）：Pro-neuregulin-1;Neuregulin-1 beta 1;NRG1-beta 1;HRG1-beta 1; EGF;NRG1; GGF; HGL; HRGA; NDF; SMDF;
- 分子量：36.7 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37667-Elabscience-PKSH031068.pdf
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL：06-6447-8641
- FAX：06-6447-8642
- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
|
89-7756-89
Recombinant Human Neuregulin-1/NRG1-‑b1 Protein (EGF Domain, Fc Tag)(Active) 5ug
|
|
|
89-7756-90
Recombinant Human Neuregulin-1/NRG1-‑b1 Protein (EGF Domain, Fc Tag)(Active) 50ug
|
よくあるご質問（FAQ）
掲載カタログ情報
| 掲載カタログ名 | 掲載ページ |
|---|