89-7756-67 ［取扱停止］Recombinant Human AGER/RAGE Protein (His Tag)(Active) 50ug PKSH031055
[Elabscience]
特徴
- 背景：Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certain members of the S100/calgranulin family of proteins, high mobility group box 1 (HMGB1), advanced oxidation protein products, and amyloid (beta-sheet fibrils). Initial studies investigating the role of RAGE in renal dysfunction focused on diabetes, neurodegenerative disorders, and inflammatory responses. However, RAGE also has roles in the pathogenesis of renal disorders that are not associated with diabetes, such as obesity-related glomerulopathy, doxorubicin-induced nephropathy, hypertensive nephropathy, lupus nephritis, renal amyloidosis, and ischemic renal injuries. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. RAGE signaling has been implicated in multiple human illnesses, including atherosclerosis, arthritis, Alzheimer's disease, atherosclerosis and aging associated diseases.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 98 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_001127
- タグ種類：C-His
- アミノ酸配列：Met 1-Ala 344
- 遺伝子構造：A DNA sequence encoding the mature form of human AGER (NP_001127) extracellular domain (Met1-Ala 344) was expressed with a polyhistidine tag at the C-terminus.
- 活性：Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human AGER-His at 10 μg/mL (100 μl/well) can bind biotinylated mouse His-S100A1 with a linear range of 15.6-250 ng/mL.3. Measured by its ability to bind biotinylated human S100A1 in functional ELISA.
- 別名（遺伝子名）：Advanced Glycosylation End Product-Specific Receptor; Receptor for Advanced Glycosylation End Products; AGER; RAGE
- 分子量：35.5 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105527-Elabscience-PKSH031055.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7756-68
Recombinant Human AGER/RAGE Protein (His Tag)(Active) 100ug
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89-7756-67
Recombinant Human AGER/RAGE Protein (His Tag)(Active) 50ug
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