89-7756-55 ［取扱停止］Recombinant Human ADM/Adrenomedullin Protein (Fc Tag) 20ug PKSH031046
[Elabscience]
特徴
- 背景：Adrenomedullin consists of 52 amino acids and is a member of the adrenomedullin family. It s a a hypotensive peptide and has 1 intramolecular disulfide bond. It seems that adrenomedullin has a slight homology with the calcitonin gene-related peptide. Adrenomedullin has a highly expression in pheochromocytoma and adrenal medulla. It also can be detected in lung, ventricle and kidney tissues. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, adrenomedullin is diuretic and natriuretic, and both adrenomedullin and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. It is believed that adrenomedullin functions through combinations of the calcitonin receptor like receptor and receptor activity-modifying proteins complexes, as well as CGRP receptors.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 93 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P35318
- タグ種類：N-Fc
- アミノ酸配列：Tyr95-Tyr146
- 遺伝子構造：A DNA sequence encoding the human ADM (P35318) (Tyr95-Tyr146) was expressed, with the fused Fc region of human IgG1 at the N-terminus.
- 別名（遺伝子名）：AM;PAMP
- 分子量：38 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37650-Elabscience-PKSH031046.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7756-55
Recombinant Human ADM/Adrenomedullin Protein (Fc Tag) 20ug
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89-7756-56
Recombinant Human ADM/Adrenomedullin Protein (Fc Tag) 50ug
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