89-7755-50 ［取扱停止］Recombinant Human Trypsin-3/PRSS3 Protein (His Tag)(Active) 10ug PKSH030980
[Elabscience]
特徴
- 背景：Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein which belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP. The trypsin inhibitor-degrading activity qualified PRSS3 as a candidate for a novel CP susceptibility gene. Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression, which is correlated with promoter hypermethylation, in esophageal squamous cell carcinoma and gastric adenocarcinoma.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P35030-3
- タグ種類：C-His
- アミノ酸配列：Met 1-Ser 247
- 遺伝子構造：A DNA sequence encoding the human PRSS3 isoform c (P35030-3) (Met 1-Ser 247) was expressed, with a polyhistidine tag at the C-terminus.
- 活性：Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (AnaSpec, Catalog#27114). The specific activity is >4,000 pmoles/min/μg.(Activation description: The proenzyme needs to be activated by enteropeptidase for an activated form)
- 別名（遺伝子名）：MTG;PRSS4;RP11-176F3.3;T9;TRY3;TRY4
- 分子量：26.6 kDa
- 組成：Lyophilized from sterile 50mM MES, 0.6M NaCl, pH 5.0
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37615-Elabscience-PKSH030980.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7755-51
Recombinant Human Trypsin-3/PRSS3 Protein (His Tag)(Active) 20ug
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89-7755-50
Recombinant Human Trypsin-3/PRSS3 Protein (His Tag)(Active) 10ug
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