89-7755-46 ［取扱停止］Recombinant Human IFN-lambda3/IL-28B Protein (Yeast, His Tag)(Active) 20ug PKSH030978
[Elabscience]
特徴
- 背景：Interleukin-28B (IL-28B) also known as Interferon lambda-3 and IFN-lambda-3, belongs to the type III interferon family of cytokines and are highly similar to IL-29. IL-28B belongs to the newly described interferon lambda (IFNlambda) family of cytokines. IL-28B is a cytokine with immunomodulatory activity. It functions in Up-regulating MHC class I antigen expression. IL-28B displays potent antiviral activity and antitumor activity. This cytokine serves as ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. IL-28B, like IL-12, is capable of robustly enhancing adaptive immunity. Moreover, we describe for the first time how IL-28B reduces regulatory T-cell populations during DNA vaccination, whereas IL-12 increases this cellular subset. We also show that IL-28B, unlike IL-12, is able to increase the percentage of splenic CD8+ T cells in vaccinated animals, and that these cells are more granular and have higher antigen-specific cytolytic degranulation compared with cells taken from animals that received IL-12 as an adjuvant.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Yeast
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：NP_742151.2
- タグ種類：C-His
- アミノ酸配列：Val18-Val196
- 遺伝子構造：A DNA sequence encoding the human IFNL3 (NP_742151.2) (Val18-Val196) was expressed with a polyhistidine tag at the C-terminus.
- 活性：Measured in antiviral assays using WISH cells infected with vesicular stomatitis virus. The ED50 for this effect is 8-40ng/mL.
- 別名（遺伝子名）：Interleukin-28B; IL-28B; Cytokine Zcyto22; Interferon Lambda-3; IFN-Lambda-3; Interferon Lambda-4; IFN-Lambda-4; Interleukin-28C; IL-28C; IL28B; IFNL3; IFNL4; IL28C; ZCYTO22
- 分子量：21.3 kDa
- 組成：Lyophilized from sterile PBS, PH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37613-Elabscience-PKSH030978.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7755-47
Recombinant Human IFN-lambda3/IL-28B Protein (Yeast, His Tag)(Active) 100ug
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89-7755-46
Recombinant Human IFN-lambda3/IL-28B Protein (Yeast, His Tag)(Active) 20ug
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