89-7755-33 Recombinant Human TGM3/Transglutaminase 3 Protein (His Tag)(Active) 100ug PKSH030971
[Elabscience]
特徴
- 背景：Transglutaminases (TGase) are a family of calcium-dependent acyl-transfer enzymes ubiquitously expressed in mammalian cells and responsible for catalyzing covalent cross-links between proteins or peptides. Transglutaminase 3 (TGM3) is a member of a family of Ca2+-dependent enzymes that catalyze covalent cross-linking reactions between proteins or peptides. TGM3 isoform is widely expressed and is important for epithelial barrier formation. It is a zymogen, requiring proteolysis for activity. Calcium-activated TGM3 can bind, hydrolyze, and is inhibited by GTP, despite lacking structural homology with other GTP binding proteins. TGM3 displays a diffuse cytoplasmic distribution in vitro consistent with its proposed role in the early phase of cornified cell envelope assembly in the cytoplasm. TGM3-driven specific isopeptide bonds between intermediate filaments and KAPs participate to the progressive scaffolding of the hair shaft. Additionally, TGM3 may be a novel prognostic biomarker for esophageal squamous cell carcinoma (ESCC).
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：Q08188
- タグ種類：N-His
- アミノ酸配列：Ala 2-Glu 693
- 遺伝子構造：A DNA sequence encoding the human TGM3 (Q08188) (Ala 2-Glu 693) was expressed, with a polyhistidine tag at the N-terminus.
- 活性：Measured by its ability to cleave a synthetic peptide Benzyloxycarbonyl-Gln-Gly and NH2OH.The specific activity is > 450 pmoles/min/μg.
- 別名（遺伝子名）：TGE
- 分子量：78.8 kDa
- 組成：Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.5, 10% gly
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37606-Elabscience-PKSH030971.pdf
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89-7755-32
Recombinant Human TGM3/Transglutaminase 3 Protein (His Tag)(Active) 50ug
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89-7755-33
Recombinant Human TGM3/Transglutaminase 3 Protein (His Tag)(Active) 100ug
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