89-7755-10 ［取扱停止］Recombinant Human ROBO4 Protein (His Tag) 50ug PKSH030956
[Elabscience]
特徴
- 背景：Roundabout homolog 4; also known as magic roundabout and ROBO4 is a member of the immunoglobulin superfamily and ROBO family. ROBO4 is specifically expressed in endothelial cells. It is expressed at sites of angiogenesis in different tumor types. ROBO4 contains two fibronectin type-III domains and two Ig-like C2-type (immunoglobulin-like) domains. ROBO4 is the fourth identified member of the roundabout receptor family. It is the only Robo family member expressed in primary endothelial cells and that application of Slit inhibits their migration. ROBO4 is predominantly expressed in embryonic or tumor vascular endothelium and is considered important for vascular development and as a candidate tumor endothelial marker. ROBO4 is a bona fide member of the Robo family and may provide a repulsive cue to migrating endothelial cells during vascular development. ROBO4 is a receptor for Slit proteins; at least for SLIT2; and seems to be involved in angiogenesis and vascular patterning. ROBO4 may mediate the inhibition of primary endothelial cell migration by Slit proteins. Activating ROBO4 may have broad therapeutic application in diseases characterized by excessive angiogenesis and/or vascular leak.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q8WZ75-1
- タグ種類：C-His
- アミノ酸配列：Met 1-Glu 469
- 遺伝子構造：A DNA sequence encoding the human ROBO4 (Q8WZ75-1) N-terminal four domains (Met 1-Glu 469) was expressed; with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：Roundabout homolog 4;Magic roundabout;ROBO4;UNQ421/PRO3674
- 分子量：49 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4; 5% glycerol
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37594-Elabscience-PKSH030956.pdf
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89-7755-11
Recombinant Human ROBO4 Protein (His Tag) 100ug
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89-7755-10
Recombinant Human ROBO4 Protein (His Tag) 50ug
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