89-7754-67 ［取扱停止］Recombinant Human VDR/NR1I1 Protein (His Tag) 20ug PKSH030931
[Elabscience]
特徴
- 背景：VDR (vitamin D(1,25- dihydroxyvitamin D3)receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X (PXR) and constitutive androstane (CAR) receptors, that form heterodimers with members of the retinoid X receptor family. VDRs repress expression of 1alpha-hydroxylase (the proximal activator of 1,25(OH)2D3) and induce expression of the 1,25(OH)2D3 inactivating enzyme CYP24. Also, it has recently been identified as an additional bile acid receptor alongside FXR and may function to protect gut against the toxic and carcinogenic effects of these endobiotics. VDR is expressed in the intestine, thyroid and kidney and has a vital role in calcium homeostasis. It is the nuclear hormone receptor, also called transcription factor that mediates the action of vitamin D3. Inherited mutations in the VDR gene leads to rickets.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 88 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P11473
- タグ種類：C-His
- アミノ酸配列：Met 1-Ser 427
- 遺伝子構造：A DNA sequence encoding the human VDR (P11473) (Met 1-Ser 427) was fused with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：NR1I1;PPP1R163
- 分子量：50 KDa
- 組成：Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0, 10% glycerol
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37578-Elabscience-PKSH030931.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7754-67
Recombinant Human VDR/NR1I1 Protein (His Tag) 20ug
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89-7754-68
Recombinant Human VDR/NR1I1 Protein (His Tag) 50ug
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