89-7754-53 ［取扱停止］Recombinant Human Interleukin-17A/IL-17A Protein (Yeast, His Tag)(Active) 50ug PKSH030924
[Elabscience]
特徴
- 背景：IL17; also known as IL17a; is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation; differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes; macrophages; dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members; IL-17/IL-17A; IL-17B; IL-17C; IL-17D; IL-17E/IL-25; and IL-17F; which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2); as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis; psoriasis and multiple sclerosis.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Yeast
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：Q16552
- タグ種類：N-His
- アミノ酸配列：Gly24-Ala155
- 遺伝子構造：A DNA sequence encoding human IL17A (Q16552) (Gly24-Ala155) was expressed with a polyhistidine tag at the N-terminus.
- 活性：Measured by its binding ability in a functional ELISA. 1.Immobilized human His-IL17A at 10μg/mL (100μL/well) can bind biotinylated human IL17Ra-His; the EC50 of biotinylated human IL17Ra-His is 0.03-0.2μg/mL.2.Measured by its ability to induce IL-6 secretion by HFF human foreskin fibroblast cells. The EC50 for this effect is typically 5-25 ng/ml.
- 別名（遺伝子名）：Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17
- 分子量：17.3 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105487-Elabscience-PKSH030924.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7754-54
Recombinant Human Interleukin-17A/IL-17A Protein (Yeast, His Tag)(Active) 100ug
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89-7754-53
Recombinant Human Interleukin-17A/IL-17A Protein (Yeast, His Tag)(Active) 50ug
|
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