89-7754-16 Recombinant Human Fumarase/FH Protein (His Tag)(Active) 100ug PKSH030901
[Elabscience]
特徴
- 背景：Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. Fumarate Hydratase is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. Individuals with hemizygous germline fumarate hydratase (FH) mutations are predisposed to renal cancer. These tumors predominantly exhibit functional inactivation of the remaining wild-type allele, implicating FH inactivation as a tumor-promoting event.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：P07954-1
- タグ種類：C-His
- アミノ酸配列：Ala 45-Lys 510
- 遺伝子構造：A DNA sequence encoding the mature form of human FH (P07954-1) (Ala 45-Lys 510) was fused with a polyhistidine tag at the C-terminus and an initial Met at the N-terminus.
- 活性：Measured by its ability to transform 1umole of Fumarate to L-malate per minute at pH 7.5 at 37¡ãC. Specific activity is > 25 unit/mg
- 別名（遺伝子名）：Fumarate Hydratase Mitochondrial; Fumarase; FH;FMRD;HLRCC;LRCC;MCL;MCUL1
- 分子量：52 kDa
- 組成：Lyophilized from sterile 10mM Tris, 5mM EDTA, 1mM DTT, pH 7.5
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37555-Elabscience-PKSH030901.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7754-16
Recombinant Human Fumarase/FH Protein (His Tag)(Active) 100ug
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89-7754-15
Recombinant Human Fumarase/FH Protein (His Tag)(Active) 50ug
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