89-7753-46 ［取扱停止］Recombinant Human APE1/APE Protein (His Tag) 20ug PKSH030851
[Elabscience]
特徴
- 背景：The enzyme is known to be a redox factor (Ref-1) stimulating DNA binding activity of AP-1 binding proteins such as Fos and Jun as well as a multifunctional DNA repair enzyme having 5' AP endonuclease; DNA 3' repair diesterase; 3'-5' exonuclease and DNA 3'-phosphatase activities.Although Apex mRNA was expressed ubiquitously; the levels varied significantly; suggesting organ- or tissue-specific expression of the Apex gene. The highest level was observed in the testis; relatively high levels in the thymus; spleen; kidney and brain; and the lowest level in the liver in rats. However; the present results suggested that APEX/Ref-1 gene product can interact with AP-1 binding proteins in brain; especially in the hippocampal formation; to regulate some brain functions by redox-activation.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 92 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P27695
- タグ種類：N-His
- アミノ酸配列：Pro2-Leu 318
- 遺伝子構造：A DNA sequence encoding the human APEX1 (P27695) (Pro2-Leu 318) was expressed; with a polyhistidine tag at the N-terminus.
- 別名（遺伝子名）：DNA-(Apurinic or Apyrimidinic Site) Lyase; APEX Nuclease; APEN; Apurinic-Apyrimidinic Endonuclease 1; AP Endonuclease 1; APE-1REF-1; Redox Factor-1; APEX1; APE; APE1; APEX; APX; HAP1; REF1
- 分子量：37 kDa
- 組成：Lyophilized from sterile PBS; pH 7.5
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105468-Elabscience-PKSH030851.pdf
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89-7753-46
Recombinant Human APE1/APE Protein (His Tag) 20ug
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89-7753-47
Recombinant Human APE1/APE Protein (His Tag) 100ug
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