89-7753-45 Recombinant Human N6AMT1/HEMK2 Protein (His Tag) 100ug PKSH030850
[Elabscience]
特徴
- 背景：Pyruvate dehydrogenase kinase, isozyme 1, also known as [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial and PDK1, is a member of the PDK / BCKDK protein kinase family. PDK-1 is expressed predominantly in the heart. It contains one histidine kinase domain. Pyruvate dehydrogenase kinase (PDK) isoforms are molecular switches that downregulate the pyruvate dehydrogenase complex (PDC) by reversible phosphorylation in mitochondria. An inhibitory effect of lipoic acid on PDKs would result in less phosphorylation of E1 and hence increased PDC activity. At least two isoenzymic forms of pyruvate dehydrogenase kinase ( PDK-1 and PDK-2 ) may be involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase complex by phosphorylation. PDK-3 appears to have the highest specific activity among the three isoenzymes. PDK-1 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：AAH11554.1
- タグ種類：C-His
- アミノ酸配列：Met 1-Ser 186
- 遺伝子構造：A DNA sequence encoding the mature form of human N6AMT1 (AAH11554.1) (Met 1-Ser 186) was fused with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：C21orf127;HEMK2;m.HsaHemK2P;MTQ2;N6AMT;PRED28
- 分子量：21.2 kDa
- 組成：Lyophilized from sterile 20mM Tris, pH 8.0
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37520-Elabscience-PKSH030850.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7753-45
Recombinant Human N6AMT1/HEMK2 Protein (His Tag) 100ug
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89-7753-44
Recombinant Human N6AMT1/HEMK2 Protein (His Tag) 50ug
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