89-7752-93 ［取扱停止］Recombinant Human Cathepsin D/CTSD Protein (His Tag)(Active) 20ug PKSH030822
[Elabscience]
特徴
- 背景：Cathepsin D (CTSD); a well known lysosomal aspartyl protease and belongs to the peptidase C1 family; which is a normal and major component of lysosomes; and is found in almost all cells and tissues of mammals. Its mostly described function is intracellular catabolism in lysosomal compartments; other physiological effect include hormone and antigen processing. Cathepsin D has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins; the generation of bioactive proteins; antigen processing; etc. Among different role in cell physiology; a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. In addition; CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin; a potent endogenous inhibitor of angiogenesis; suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P07339
- タグ種類：C-His
- アミノ酸配列：Met 1-Leu 412
- 遺伝子構造：A DNA sequence encoding the pro form of human CTSD (P07339) (Met 1-Leu 412) was fused with a polyhistidine tag at the C-terminus.
- 活性：Measured by its ability to bind biotinylated human CTSS-His in a functional ELISA.
- 別名（遺伝子名）：Cathepsin D; CTSD;CLN10;CPSD;HEL-S-130P
- 分子量：44 kDa
- 組成：Lyophilized from sterile 25mM MES; 150mM NaCl; pH 6.5
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37505-Elabscience-PKSH030822.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7752-92
Recombinant Human Cathepsin D/CTSD Protein (His Tag)(Active) 10ug
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89-7752-93
Recombinant Human Cathepsin D/CTSD Protein (His Tag)(Active) 20ug
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