89-7752-82 ［取扱停止］Recombinant Human Thioredoxin-2/TXN2 Protein (His Tag)(Active) 20ug PKSH030817
[Elabscience]
特徴
- 背景：Thioredoxin-2; also known as TXN2; MTRX and TRX2; is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which; as trypanothione:peroxiredoxin oxidoreductases; constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small redox protein important in cellular antioxidant defenses; as well as in the regulation of apoptosis. Thioredoxin-2 / TXN2 has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Thioredoxin-2 / TXN2 could be involved in the resistance to anti-tumor agents. It possesses a dithiol-reducing activity. Thioredoxin-2 / TXN2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis. Mammalian Thioredoxin-2 / TXN2 is a mitochondrial isoform of highly evolutionary conserved thioredoxins. Thioredoxins are small ubiquitous protein-disulfide oxidoreductases implicated in a large variety of biological functions.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：Q99757
- タグ種類：N-His
- アミノ酸配列：Thr 60-Gly 166
- 遺伝子構造：A DNA sequence encoding the mature form of human TXN2 (Q99757) (Thr 60-Gly 166) was expressed; with a polyhistide tag at the N-terminus.
- 活性：Measured by its ability to catalyze the reduction of insulin. The reaction leads to precipitation; which can be measured by absorbance at 650 nm. The specific activity is 5-8 A650/min/mg.
- 別名（遺伝子名）：Thioredoxin Mitochondrial; MTRX; Mt-Trx; Thioredoxin-2; TXN2; TRX2
- 分子量：13.4 kDa
- 組成：Lyophilized from sterile PBS; pH 8.3
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37501-Elabscience-PKSH030817.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7752-83
Recombinant Human Thioredoxin-2/TXN2 Protein (His Tag)(Active) 100ug
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89-7752-82
Recombinant Human Thioredoxin-2/TXN2 Protein (His Tag)(Active) 20ug
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