89-7752-32 ［取扱停止］Recombinant Human Neuritin/NRN1 Protein (Baculovirus, His Tag) 20ug PKSH030790
[Elabscience]
特徴
- 背景：Neuritin 1 (NRN1) is a member of neuritin family. Neuritin is a glycosylphosphatidylinositol- anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervous system and a population of small-diameter neurons in the dorsal root ganglia and was anterogradely and retrogradely transported. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF; nerve growth factor (NGF) and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures. Thus; neuritin is considered as a downstream effector of activity-induced neurite outgrowth. In clinical; neuritin levels in diabetes were reduced in both dorsal root ganglia and sciatic nerve of rats; and these deficits were reversed in vivo by treatment with NGF. This manipulation of neuritin levels in diabetes may provide a potential target for the therapeutic intervention in the management of neuropathy.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q9NPD7
- タグ種類：C-His
- アミノ酸配列：Met 1-Asn 115
- 遺伝子構造：A DNA sequence encoding the mature form of human NRN1 (Q9NPD7) (Met 1-Asn 115) was fused with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：dJ380B8.2;MGC44811;NRN
- 分子量：
- 組成：Lyophilized from sterile 20mM Tris; 500mM NaCl; pH 8.0; 10% gly
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37478-Elabscience-PKSH030790.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7752-33
Recombinant Human Neuritin/NRN1 Protein (Baculovirus, His Tag) 50ug
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89-7752-32
Recombinant Human Neuritin/NRN1 Protein (Baculovirus, His Tag) 20ug
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