89-7752-12 ［取扱停止］Recombinant Human SERPINB9/PI-9 Protein (Baculovirus, His Tag) 50ug PKSH030777
[Elabscience]
特徴
- 背景：SerpinB9; also known as Cytoplasmic antiproteinase 3; CAP-3; Peptidase inhibitor 9; SERPINB9 and PI-9; is a cytoplasm protein which belongs to the serpin family and Ov-serpin subfamily. Serpin-B9 ( CAP-3 / PI-9 ) is the only known human intracellular inhibitor of granzyme B (GrB); the effector molecule in immunity against cytomegalovirus (CMV) and in renal allograft rejection. Serpin-B9 and SPI-6 expression in immune-privileged cells; APCs; and CTLs protects these cells against the actions of granzyme B; and when expressed in tumor cells or virally infected hepatocytes; confers resistance to killing by CTL and NK cells. Expression of increasing levels of Serpin-B9 ( CAP-3 / PI-9 ) in target cells may progressively inhibit immune surveillance by blocking NK and CTL-induced cytotoxicity through the perforin / granzyme pathway and then through the Fas / FasL pathway. Serpin-B9 ( CAP-3 / PI-9 ) is selectively up-regulated in hepatocytes in response to infiltration of the liver by NK cells that express perforin and enzymatically active granzyme B. Upregulated expression of Serpin-B9 ( CAP-3 / PI-9 ) in NSCLC cells may serve to protect them from apoptosis induced by GrB.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：P50453
- タグ種類：N-His
- アミノ酸配列：Glu 2-Pro 376
- 遺伝子構造：A DNA sequence encoding the human SERPINB9 (P50453) (Glu 2-Pro 376) was expressed; with a polyhistidine tag at the N-terminus.
- 別名（遺伝子名）：Cytoplasmic antiproteinase 3;Peptidase inhibitor 9;CAP3;PI-9;Serpin B9
- 分子量：44.5 kDa
- 組成：Lyophilized from sterile 50mM Tris; 100mM NaCl; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37467-Elabscience-PKSH030777.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7752-12
Recombinant Human SERPINB9/PI-9 Protein (Baculovirus, His Tag) 50ug
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89-7752-13
Recombinant Human SERPINB9/PI-9 Protein (Baculovirus, His Tag) 100ug
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