89-7751-97 ［取扱停止］Recombinant Human PTPMT1 Protein (His Tag)(Active) 20ug PKSH030769
[Elabscience]
特徴
- 背景：PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. It has been recently reported that PTPMT1 dephosphorylates phosphatidylglycerol phosphate, an essential intermediate of cardiolipin biosynthesis. PTPMT1 deficiency in mouse embryonic fibroblasts compromises mitochondrial respiration and results in abnormal mitochondrial morphology. Lipid analysis of PTPMT1-deficient fibroblasts reveals an accumulation of PGP along with a concomitant decrease in phosphatidylglycerol. Modulation of mitochondrial ATP synthesis by PTPMT1 suggests a novel approach for the treatment of pancreatic cancers, which represent some of the deadliest forms of human tumors. The gluttony of cancer cells for energy is well established, and with the development of a modulator of expression, one may hope that we could also achieve the synthetic induction of PTPMT1 expression. It would then be expected that this effect would attenuate, if not abolish, the growth of pancreas-derived tumor cells and support the establishment of a novel regimen for pancreatic cancers.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 94 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：Q8WUK0-1
- タグ種類：N-His
- アミノ酸配列：Lys 28-Thr 201
- 遺伝子構造：A DNA sequence encoding the human PTPMT1 isoform 1 (Q8WUK0-1) (Lys 28-Thr 201) was expressed, with a polyhistidine tag at the N-terminus.
- 活性：Measured by its ability to cleave pNPP.The specific activity is >200 pmoles/min/μg.
- 別名（遺伝子名）：DUSP23;FLJ46081;MOSP;PLIP;PNAS-129
- 分子量：21.7 kDa
- 組成：Lyophilized from sterile PBS, 10% glycerol, 1mM DTT, pH 7.5
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37462-Elabscience-PKSH030769.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7751-98
Recombinant Human PTPMT1 Protein (His Tag)(Active) 50ug
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89-7751-97
Recombinant Human PTPMT1 Protein (His Tag)(Active) 20ug
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