89-7751-91 ［取扱停止］Recombinant Human Uracil-DNA glycosylase/UNG Protein (GST Tag) 20ug PKSH030766
[Elabscience]
特徴
- 背景：Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells. Uracil-DNA glycosylase exists in two forms: mitochondrial uracil-DNA glycosylase 1 (UNG1) and nuclear uracil-DNA glycosylase 2 (UNG2). uracil-DNA glycosylase. This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5). A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：P13051-2
- タグ種類：N-GST
- アミノ酸配列：Phe 85-Leu 304
- 遺伝子構造：A DNA sequence encoding the human UNG isoform 1 (P13051-2) (Phe 85-Leu 304) was fused with the GST tag at the N-terminus.
- 別名（遺伝子名）：DGU;HIGM4;HIGM5;UDG;UNG1;UNG15;UNG2
- 分子量：52 kDa
- 組成：Lyophilized from sterile 40mM Tris, 0.15M NaCl, 2mM GSH, pH 7.5
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105446-Elabscience-PKSH030766.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7751-91
Recombinant Human Uracil-DNA glycosylase/UNG Protein (GST Tag) 20ug
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89-7751-92
Recombinant Human Uracil-DNA glycosylase/UNG Protein (GST Tag) 100ug
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