特徴
- 背景：USP46 belongs to the peptidase C19 family; USP12/USP46 subfamily. Deubiquitinating enzymes (DUBs) are a large group of proteases which are also commonly referred to as deubiquitinating peptidases; deubiquitinating isopeptidases; deubiquitinases; ubiquitin proteases; ubiquitin hydrolyases; ubiquitin isopeptidases; or Dubs. They regulate ubiquitin-dependent metabolic pathways by cleaving ubiquitin-protein bonds. They also may act as negative and positive regulators of the ubiquitin system. Besides ubiquitin recycling; they are also involved in processing of ubiquitin precursors; in proofreading of protein ubiquitination and in disassembly of inhibitory ubiquitin chains. USP46 is a deubiquitinating enzyme that plays a role in behavior; possibly by regulating GABA action. It may act by mediating the deubiquitination of GAD1/GAD67. USP46 has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity and it is not involved in deubiquitination of monoubiquitinated FANCD2.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_808229.1
- タグ種類：N-SUMO
- アミノ酸配列：Met 1-Glu366
- 遺伝子構造：A DNA sequence encoding the human USP46 [(Identical to the mouse USP46 (NP_808229.1)] (Met1-Glu366) was expressed and purified.
- 別名（遺伝子名）：USP46
- 分子量：55.2 kDa
- 組成：Lyophilized from sterile 20mM Tris; 500mM NaCl; pH 7.4; 10% gly
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37459-Elabscience-PKSH030765.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7751-90
Recombinant Human/Mouse USP46 Protein 100ug
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89-7751-89
Recombinant Human/Mouse USP46 Protein 20ug
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