89-7751-79 ［取扱停止］Recombinant Human SELP/selectin P/P-selectin Protein (Fc Tag)(Active) 50ug PKSH030759
[Elabscience]
特徴
- 背景：P selectin (SELP) is a 140kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. SELP mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P selectin is a cell adhesion molecule on the surface of activated endothelial cells. Cellular adhesion molecules are a large family of proteins that attach the cytoskeleton and intracellular signaling cascades with the extracellular environment. SELP is a calcium-dependent receptor for myeloid cells that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interacton of activated endothelial cells or platelets with leukocytes.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：AAN06828.1
- タグ種類：C-Fc
- アミノ酸配列：Met 1-Ala 771
- 遺伝子構造：A DNA sequence encoding the human SELP (AAN06828.1) extracellular domain (Met 1-Ala 771) was fused with the Fc region of human IgG1 at the C-terminus.
- 活性：Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When 5 x 10E4 cells/well are added to SELP/Fc Chimera coated plates (10 μg/mL with 100 μL/well), > 80% cells will adhere after 1 hour at 37℃.
- 別名（遺伝子名）：CD62;CD62P;GMP140;GRMP;LECAM3;P-Selectin;PADGEM;PSEL
- 分子量：107 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105443-Elabscience-PKSH030759.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7751-79
Recombinant Human SELP/selectin P/P-selectin Protein (Fc Tag)(Active) 50ug
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89-7751-80
Recombinant Human SELP/selectin P/P-selectin Protein (Fc Tag)(Active) 100ug
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