89-7751-76 Recombinant Human RTN4/NOGO-A Protein (GST Tag)(Active) 100ug PKSH030757
[Elabscience]
特徴
- 背景：Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein which contains one reticulon domain. Isoform 1 of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 of RTN4 is widely expressed except for the liver. Isoform 3 of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 of RTN4 is testis-specific. Reticulon-4 / RTN4 is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Reticulon-4 / RTN4 regulates neurite fasciculation, branching and extension in the developing nervous system. Reticulon-4 / RTN4 is involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. It regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 of RTN4 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 of RTN4 inhibit BACE1 activity and amyloid precursor protein processing.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 92 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：NP_065393.1
- タグ種類：N-GST
- アミノ酸配列：Met 1-Val 185
- 遺伝子構造：A DNA sequence encoding the human RTN4 (NP_065393.1) N-terminal fragment (Met 1-Val 185) was fused with the GST tag at the N-terminus.
- 活性：Measured by its ability to bind recombinant human RTN4R in a functional ELISA.
- 別名（遺伝子名）：ASY;DGU;DKFZp781L1143;HIGM4;Nbla00271;Nbla10545;NI220/250;NOGO;NOGO-A;Nogo-B;Nogo-C;NOGOC;NSP;NSP-CL;RTN-X;RTN4-A;RTN4-B1;RTN4-B2;RTN4-C;UDG;UNG1;UNG15;UNG2
- 分子量：46.2 kDa
- 組成：Lyophilized from sterile 20mM Tris, 150mM NaCl, 1mM DTT, 0.2mM GSH, pH 7.0
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37454-Elabscience-PKSH030757.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7751-75
Recombinant Human RTN4/NOGO-A Protein (GST Tag)(Active) 50ug
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89-7751-76
Recombinant Human RTN4/NOGO-A Protein (GST Tag)(Active) 100ug
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