89-7751-71 ［取扱停止］Recombinant Human IL1RL1/ST2 Protein (isoform a, His Tag)(Active) 50ug PKSH030755
[Elabscience]
特徴
- 背景：IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 98 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_057316.3
- タグ種類：C-His
- アミノ酸配列：Met 1-Ser 328
- 遺伝子構造：A DNA sequence encoding the human IL1RL1 isoform A (NP_057316.3) (Met 1-Ser 328) was expressed, fused with a polyhistidine tag at the C-terminus.
- 活性：Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human IL33 at 10 μg/mL (100 μl/well) can bind biotinylated human IL1RL1 (isoform A) with a linear range of 0.032-8 μg/ml.
- 別名（遺伝子名）：DER4;FIT-1;IL1RL1;IL33R;IL‑1 R4;ST2;ST2L;ST2V;T1
- 分子量：36.3 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105442-Elabscience-PKSH030755.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7751-71
Recombinant Human IL1RL1/ST2 Protein (isoform a, His Tag)(Active) 50ug
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89-7751-72
Recombinant Human IL1RL1/ST2 Protein (isoform a, His Tag)(Active) 100ug
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