特徴
- 背景：KIR2DL4, also known as CD158d, is a member of the killer cell Ig-like receptor (KIR) family. KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：CHO Stable Cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：ADY38409.1
- アミノ酸配列：Met 1-His242
- 遺伝子構造：A DNA sequence encoding the human KIR2DL4 (ADY38409.1)(Met1-His242) was expressed with six amino acids (LEVLFQ) at the C-terminus was expressed and purified.
- 別名（遺伝子名）：Killer Cell Immunoglobulin-Like Receptor 2DL4; CD158 Antigen-Like Family Member D; G9P; Killer Cell Inhibitory Receptor 103AS; KIR-103AS; MHC Class I NK Cell Receptor KIR103AS; CD158d; KIR2DL4; CD158D; KIR103AS
- 分子量：25.1 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37451-Elabscience-PKSH030752.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7751-68
Recombinant Human KIR2DL4/CD158D Protein 100ug
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89-7751-67
Recombinant Human KIR2DL4/CD158D Protein 50ug
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