89-7751-41 ［取扱停止］Recombinant Human IL17BR/IL17RB Protein (Fc Tag)(Active) 50ug PKSH030736
[Elabscience]
特徴
- 背景：R-spondin-2; also known as RSPO2; synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene activation. Action both in the canonical Wnt / beta- catenin-dependent pathway; possibly via a direct interaction with Wnt proteins; and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled / LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors. The encoding gene Rspo2 was identified as a novel common integration site for the mouse mammary tumor virus in viral induced mouse mammary tumors. Rspo2 and Rspo2 / Wnt1 tumors contained many spindle cells; consistent with an epithelial-mesenchymal transformation phenotype. When Rspo2 and Rspo2 / Wnt1 tumor cells were transferred into naive mice; they exhibited greater metastatic activity than cells derived from Wnt1 tumors.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_061195.2
- タグ種類：C-Fc
- アミノ酸配列：Met 1-Gly289
- 遺伝子構造：A DNA sequence encoding the human IL17BR (NP_061195.2) (Met1-Gly289) was expressed with the Fc region of human IgG1 at the C-terminus.
- 活性：Measured by its binding ability in a functional ELISA. Immobilized human IL17BR-Fc at 10μg/mL (100μL/well) can bind biotinylated human Fc-IL25.The EC50 of human Fc-IL25 is 4.5-10.4ng/mL.
- 別名（遺伝子名）：CRL4;EVI27;IL17BR;IL17RH1
- 分子量：56.9 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105439-Elabscience-PKSH030736.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7751-41
Recombinant Human IL17BR/IL17RB Protein (Fc Tag)(Active) 50ug
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89-7751-42
Recombinant Human IL17BR/IL17RB Protein (Fc Tag)(Active) 100ug
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