89-7751-39 ［取扱停止］Recombinant Human IL17BR/IL17RB Protein (His Tag)(Active) 50ug PKSH030735
[Elabscience]
特徴
- 背景：MTSS1 (Metastasis suppressor 1); also known as Missing in metastasis (MIM); is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expressed in a variety of tissues. MTSS1 might be involved in shaping neuronal membranes in vivo. MTSS1 deforms phosphoinositide-rich membranes through its I-BAR domain and interacts with actin monomers through its WH2 domain. MTSS1/MIM was first identified as a metastasis suppressor missing in metastatic bladder carcinoma cell lines. MTSS1 is a prognostic indicator of disease-free survival in breast cancer patients and demonstrates the ability to play a role in governing the metastatic nature of breast cancer cells. MTSS1 may serve as a useful biomarker for the prediction of outcome of gastric cancer. The down-regulation of MTSS1 that may be caused by DNA methylation was also observed in many other types of cancer.Recent work proposed that MIM also potentiates Sonic hedgehog (Shh)-induced gene expression. MTSS1 as a multiple functional molecular player and has an important role in development; carcinogenesis and metastasis.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_061195.2
- タグ種類：C-His
- アミノ酸配列：Met 1-Gly289
- 遺伝子構造：A DNA sequence encoding the human IL17BR (NP_061195.2) (Met1-Gly289) was expressed with a C-terminal polyhistidine tag.
- 活性：Measured by its binding ability in a functional ELISA.Immobilized human IL17BR-His at 10 μg/ml (100 μl/well) can bind human Fc-IL25 ; The EC50 of human Fc-IL25 is 0.1-0.3 μg/ml.
- 別名（遺伝子名）：CRL4;EVI27;IL17BR;IL17RH1
- 分子量：31.5 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37438-Elabscience-PKSH030735.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7751-39
Recombinant Human IL17BR/IL17RB Protein (His Tag)(Active) 50ug
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89-7751-40
Recombinant Human IL17BR/IL17RB Protein (His Tag)(Active) 100ug
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