89-7750-99 Recombinant Human KIR2DL1/CD158a Protein (Fc Tag) 50ug PKSH030712
[Elabscience]
特徴
- 背景：Killer cell immunoglobulin-like receptor 2DL1 or KIR2DL1 is an inhibitory natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 is a member of the Killer cell immunoglobulin-like receptor family whose members are classified by the number of the extracellular immunoglobulin domains and the length of the cytoplasm domain. KIR2DL1 is a transmembrane glycoprotein expressed by natural killer cells and subsets of T cells. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 bound to its class I MHC ligand; HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4. Many residues conserved in HLA-C and in KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and in a previously reported KIR2DL2-HLA-Cw3 complex. A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_055033.2
- タグ種類：C-Fc
- アミノ酸配列：Met 1-His 245
- 遺伝子構造：A DNA sequence encoding the human KIR2DL1 (NP_055033.2) extracellular domain (Met 1-His 245) was fused with the Fc region of human IgG1 at the C-terminus.
- 別名（遺伝子名）：CD158A;KIR-K64;KIR221;NKAT;NKAT-1;NKAT1;p58.1;XXbac-BCX195L8.1;XXbac-BPG184J6.7
- 分子量：51.7 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37422-Elabscience-PKSH030712.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7750-99
Recombinant Human KIR2DL1/CD158a Protein (Fc Tag) 50ug
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89-7750-98
Recombinant Human KIR2DL1/CD158a Protein (Fc Tag) 20ug
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