89-7750-72 ［取扱停止］Recombinant Human SerpinB3/SCCA1 Protein (His Tag)(Active) 10ug PKSH030698
[Elabscience]
特徴
- 背景：SERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. SERPINB3 is expressed in some hepatocellular carcinoma (at protein level). Its expression is closely related to cellular differentiation in both normal and malignant squamous cells. It seems to also be secreted in plasma by cancerous cells but at a low level. SERPINB3 significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells. It may act as a protease inhibitor to modulate the host immune response against tumor cells and may be involved in the malignant behavior of squamous cell carcinoma cells.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：AAB20405.1
- タグ種類：N-His
- アミノ酸配列：Asn 2-Pro 390
- 遺伝子構造：A DNA sequence encoding the human SERPINB3 (AAB20405.1) (Asn 2-Pro 390) was expressed, with a polyhistidine tag at the N-terminus.
- 活性：Measured by its ability to inhibit active Cathepsin L cleavage of a fluorogenice peptide substrate Z-LR-AMC, R&D Systems, Catalog # ES008.The IC50 is < 5 nM.
- 別名（遺伝子名）：Serpin B3; Protein T4-A; Squamous cell carcinoma antigen 1; SCCA-1;serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3; serpin peptidase inhibitor, clade B (ovalbumin), member 3; Squamous cell carcinoma antigen 1;T4-A;SCCA1;HsT1196;SCC;SCCA-1;SCCA-PD
- 分子量：46.7 kDa
- 組成：Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 20% gly, 3mM DTT
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37409-Elabscience-PKSH030698.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7750-73
Recombinant Human SerpinB3/SCCA1 Protein (His Tag)(Active) 20ug
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89-7750-72
Recombinant Human SerpinB3/SCCA1 Protein (His Tag)(Active) 10ug
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