89-7750-69 Recombinant Human IFNAR1/IFNAR Protein (His Tag) 100ug PKSH030695
[Elabscience]
特徴
- 背景：Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases; which in turn phosphorylate several proteins; including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due; at least in part; to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1; in which Tyr466 is changed to phenylalanine; can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P17181-1
- タグ種類：C-His
- アミノ酸配列：Met 1-Lys 436
- 遺伝子構造：A DNA sequence encoding the human IFNAR1 isoform 1 (P17181-1) extracellular domain (Met 1-Lys 436) was fused with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：Interferon Alpha/Beta Receptor 1; IFN-R-1; IFN-Alpha/Beta Receptor 1; Cytokine Receptor Class-II Member 1; Cytokine Receptor Family 2 Member 1; CRF2-1; Type I Interferon Receptor 1;IFNAR1;IFNAR;AVP;IFN-alpha-REC
- 分子量：48.6 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37406-Elabscience-PKSH030695.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7750-68
Recombinant Human IFNAR1/IFNAR Protein (His Tag) 50ug
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89-7750-69
Recombinant Human IFNAR1/IFNAR Protein (His Tag) 100ug
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