89-7750-60 ［取扱停止］Recombinant Human Alkaline Phosphatase/ALPI Protein (Fc Tag)(Active) 20ug PKSH030691
[Elabscience]
特徴
- 背景：Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases; which in turn phosphorylate several proteins; including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due; at least in part; to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1; in which Tyr466 is changed to phenylalanine; can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 83 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：P09923
- タグ種類：C-Fc
- アミノ酸配列：Met 1-Asp 503
- 遺伝子構造：A DNA sequence encoding the mature form of human ALPI (P09923) (Met 1-Asp 503);without the pro peptide; was fused with a polyhistidine tag at the C-terminus.
- 活性：Measured by its ability to cleave a fluorogenic substrate; 4-Methylumbelliferyl phosphate (4-MUP).The specific activity is > 10;000 pmoles/min/μg.
- 別名（遺伝子名）：IAP
- 分子量：79.5 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37403-Elabscience-PKSH030691.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7750-61
Recombinant Human Alkaline Phosphatase/ALPI Protein (Fc Tag)(Active) 50ug
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89-7750-60
Recombinant Human Alkaline Phosphatase/ALPI Protein (Fc Tag)(Active) 20ug
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