89-7750-46 ［取扱停止］Recombinant Human AFM/Afamin Protein (His Tag) 20ug PKSH030684
[Elabscience]
特徴
- 背景：Afamin is an 87 kDa glycoprotein with five predicted N-glycosylation sites. Afamin's glycan abundance contributes to conformational and chemical inhomogeneity presenting great challenges for molecular structure determination. Afamin, a human plasma glycoprotein and putative transporter of hydrophobic molecules, has been shown to act as extracellular chaperone for poorly soluble, acylated Wnt proteins, forming a stable, soluble complex with functioning Wnt proteins. The 2.1-Å crystal structure of glycosylated human afamin reveals an almost exclusively hydrophobic binding cleft capable of harboring large hydrophobic moieties. Afamin plays a role in anti-apoptotic cellular processes related to oxidative stress and is associated with insulin resistance and other features of metabolic syndrome. Afamin may serve as a new early biomarker for pathological glucose metabolism during pregnancy. And first trimester screening for pre-eclampsia could be provided by a combination of afamin and placental bed vascularization. Moreover, the combination of first trimester serum afamin levels with BMI could provide a possible screening for gestational diabetes mellitus.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：P43652
- タグ種類：C-His
- アミノ酸配列：Met 1-Asn599
- 遺伝子構造：A DNA sequence encoding the human AFM (P43652) (Met1-Asn599) was expressed with a C-terminal polyhistidine tag.
- 別名（遺伝子名）：ALB2;ALBA;ALF
- 分子量：68 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105425-Elabscience-PKSH030684.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7750-46
Recombinant Human AFM/Afamin Protein (His Tag) 20ug
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89-7750-47
Recombinant Human AFM/Afamin Protein (His Tag) 50ug
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