89-7748-85 ［取扱停止］Recombinant Human PPP3CA/CALNA Protein (His Tag)(Active) 20ug PKSH030577
[Elabscience]
特徴
- 背景：PPP3CA, also known as protein phosphatase 2B, is a member of the PPP phosphatase family, PP-2B subfamily. It is the alpha catalytic subunit of protein phosphatase 2B (PP2B). PP2B is a holoenzyme that is comprised of a catalytic subunit associated with regulatory subunits. It is a calcium regulated enzyme that is activated by calmodulin and participates in the signaling cascades involved in development of the nervous, cardiovascular, and musculoskeletal systems. PPP3CA activates the T cells of the immune system and can be blocked by drugs. It also activates NFATc (a transcription factor) by dephosphorylating it. The activated NFATc is subsequently translocated into the nucleus, where it upregulates the expression of interleukin 2. PPP3CA interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. It also interacts with DNM1L. The interaction dephosphorylates DNM1L and regulates its translocation to mitochondria.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 94 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：Q08209-1
- タグ種類：N-His
- アミノ酸配列：Ser2-Gln521
- 遺伝子構造：A DNA sequence encoding the human PPP3CA (Q08209-1) (Ser2-Gln521) was fused with a polyhistide tag at the N-terminus.
- 活性：Using the Octet RED System, the affinity constant (Kd) of human PPPP3CA-His bound to Human PPIA-His was 0.9 nM.
- 別名（遺伝子名）：CALN;CALNA;CALNA1;CCN1;CNA1;PPP2B
- 分子量：60.8 kDa
- 組成：Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% glycerol
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37331-Elabscience-PKSH030577.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7748-85
Recombinant Human PPP3CA/CALNA Protein (His Tag)(Active) 20ug
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89-7748-84
Recombinant Human PPP3CA/CALNA Protein (His Tag)(Active) 10ug
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