89-7748-82 ［取扱停止］Recombinant Human Calcineurin B/CNB Protein (His Tag)(Active) 20ug PKSH030576
[Elabscience]
特徴
- 背景：PPP3R1 belongs to the calcineurin regulatory subunit family. It is a regulatory subunit of calcineurin. Calcineurin is composed of two subunits: calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nuclear factor of activated T-cells (NF-AT) by Calcineurin is essential for NF-AT activation; nuclear translocation; and early gene expression in T-cells. PPP3R1 is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase which takes a vital part in the T cell activation pathway. PPP3R1 is involved in protein dephosphorylation; NFAT protein import into nucleus (ortholog) and epithelial to mesenchymal transition (ortholog). It participates in calcineurin signaling pathway; mitogen activated protein kinase signaling pathway. PPP3R1 interacts with (+)-pilocarpine; 2;4-dinitrotoluene and ammonium chloride. It contains four EF-hand domains and four functional calcium-binding sites. PPP3R1 play an improtant role in the T cell activation pathway.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 87 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P63098
- タグ種類：N-His
- アミノ酸配列：Gly2-Val170
- 遺伝子構造：A DNA sequence encoding the human PPP3R1 (P63098) (Gly2-Val170) was fused with a polyhistide tag at the N-terminus.
- 活性：Using the Octet RED System; the affinity constant (Kd) of human PPP3R1-His bound to Human PPIA-His was 6 nM.
- 別名（遺伝子名）：Calcineurin Subunit B Type 1; Protein Phosphatase 2B Regulatory Subunit 1; Protein Phosphatase 3 Regulatory Subunit B Alpha Osoform 1; PPP3R1; CNA2; CNB
- 分子量：21.4 kDa
- 組成：Lyophilized from sterile 50mM Tris; 100mM NaCl; pH 8.0; 10% glycerol; 2mM DTT
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105398-Elabscience-PKSH030576.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7748-83
Recombinant Human Calcineurin B/CNB Protein (His Tag)(Active) 100ug
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89-7748-82
Recombinant Human Calcineurin B/CNB Protein (His Tag)(Active) 20ug
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